Cancer Research Center

Columbia, MO, United States

  • Health

  • Missouri | Global Programs

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  • Public charity

  • $1,347,867

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Executive Summary

Cancer is killing people all over the world every day, especially Pancreatic Cancer. The National Cancer Institute estimates 53,000 Americans will be diagnosed with pancreatic cancer this year. Nearly 42,000 will die from it. The five year survival rate is 8%. Our scientists are working with a strain of Salmonella bacteria that is not toxic and is drawn to cancer cells. In a petri dish and in mouse trials it has proven to invade prostate tumors without poisoning the healthy cells. We know this to be true on a cellular level for breast, colon, pancreatic cancers, and melanoma. The bacterium also carries therapies directly to the cancer site so that only the cancer cells are affected by the treatment. We are eager to further this research so patients with various cancers may benefit, but especially cancers such as pancreatic where there is no viable treatment.

The Problem

Cancer and the current treatments are the problem. Physicians are treating cancer patients through surgery, radiation, and chemotherapy or a combination of all three. Each of these options carries undesirable side effects. Furthermore, they are not always effective. Pancreatic cancer, for example, is the 12th most common cancer in the United States and the fourth leading cause of cancer related deaths in both men and women.

Proposed Solution

Bacteriotherapy is the solution to resolve pancreatic cancer due to bacteria's ability to specifically target, invade, and successfully infiltrate tumors of all sizes. We have engineered a strain of Salmonella that targets cancer and keeps it from growing. It sets up camp within tumors and destroys them. We have performed mouse studies using this Bacteriotherapy against prostate cancer because those mice were the most available to us. We found the bacteria went straight to the prostate tumors, attacked them, and did not settle in any other organs. The mice showed no ill effects. We tested colon cancer, breast cancer, melanoma, and most importantly pancreatic cancer with the same results at a cellular level. We have a patent for this therapy.

Evidence of Effectiveness

The evidence that our solution will work is in the results of the research we have already completed. We have also published journal articles which can be found on PubMed Central: Wand CZ, Kazmierczak RA, EisenstarkA. Strains, Mechanism, and Perspective: Salmonella Based Cancer Therapy. Int J Microbiology 2016

Previous Performance

The Cancer Research Center developed the therapeutic bacterial strain from part of a collection that has been stored for over 40 years. Only two of these collections exist. The other was frozen while ours was stored at room temperature. Because the bacteria had no nourishment, they let go of characteristics that were not necessary for survival. One of these traits was their ability to make you sick, their toxicity. Similarly, if we find ourselves facing a flood and have to evacuate only taking what will fit in a lifeboat, we leave behind things that are not necessary for survival. This makes our strain unique as it released its toxicity voluntarily. We engineered it further for improved targeting performance.

The Team

Team Purpose

The Cancer Research Center mission is to conduct and sponsor research to reduce cancer deaths by earlier detection, novel therapies, and identification of environmental and nutritional components that reduce tumor initiation. We are researching every day for a healthier tomorrow. Our scientists are developing a Bacteriotherapy that will allow physicians to treat cancer without poisoning the patient.

Team Structure

The Cancer Research Center is overseen by a Board of Trustees. The overall operations are managed by an Administrative Director who also oversees the Research Director and Development Director, as well as any of their staff. The research staff members meet bi weekly to remain current with different aspects of the scientific progress. They also collaborate with other scientists in their field via scientific meetings and email.